Fig. 1.

Cartoon showing examples of mechanoreceptors constituted by single molecules or protein complexes. Protein structures were obtained from Protein Data Bank (rcsb.org; (Berman et al. 2000)) and were generated by NGL Viewer (Rose et al. 2018). Integrin cartoon represents human AlphaVBeta3 integrin structure (PDB reference: 4O02; (Mahalingam et al. 2014)). Catenin cartoon represents human beta-catenin structure (PDB reference: 4DJS; (Grossmann et al. 2012)). Cadherin cartoon represents mouse N-cadherin ectodomain crystal structure (PDB reference: 3Q2W; (Harrison et al. 2011)). Connexin cartoon represents human Connexin-26 structure (PDB reference: 5ERA; (Bennett et al. 2016)). Ion channel cartoon represents mouse mechanosensitive Piezo1 channel structure (PDB reference: 5Z10; (Zhao et al. 2018))