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GSK3b regulates inflammation. Active GSK3b promotes NFkB stability and nuclear localization downstream of toll-like receptor (TLR) signaling, leading to the production of pro-inflammatory cytokines. Conversely, GSK3b blocks nuclear accumulation of CREB by promoting its degradation. GSK3b also promotes the integrity of TLR signaling by stabilizing NEMO, a factor that promotes the DNA binding activity of NFkB
