Appendix Table 3.
Sensitivity Analysis of Association Between Patterns of Inpatient Opioid Administration and Outpatient Opioid Use at 90 and 365 Days After Discharge Among Inpatients Receiving Opioids, With Hospital 1 Excluded
| Variable | ≤90 Days After Discharge | ≤365 Days After Discharge | ||
|---|---|---|---|---|
| Outpatient Opioid Use (95% CI), % | Difference (95% CI), percentage points | Outpatient Opioid Use (95% CI), % | Difference (95% CI), percentage points | |
| Proportion of stay with opioids administered | ||||
| 1%–25% | 6.0 (5.3 to 6.7) | Reference | 7.1 (6.4 to 7.8) | Reference |
| 26%–50% | 6.0 (5.6 to 6.4) | 0.0 (−0.7 to 0.7) | 7.9 (7.4 to 8.3) | 0.8 (0.1 to 1.5) |
| 51%–75% | 7.3 (7.0 to 7.7) | 1.3 (0.6 to 2.0) | 9.5 (9.0 to 9.9) | 2.4 (1.7 to 3.1) |
| 76%–100% | 7.2 (6.7 to 7.7) | 1.2 (0.5 to 1.9) | 9.3 (8.7 to 9.8) | 2.2 (1.5 to 2.9) |
| Time from last opioid administration to discharge | ||||
| >24 h | 4.6 (4.2 to 4.9) | Reference | 6.3 (5.9 to 6.7) | Reference |
| 13–24 h | 6.5 (5.9 to 7.0) | 1.9 (1.3 to 2.4) | 8.0 (7.4 to 8.6) | 1.7 (1.1 to 2.3) |
| 0–12 h | 8.5(8.1 to 8.8) | 3.9 (3.5 to 4.2) | 10.5 (10.0 to 10.9) | 4.2 (3.7 to 4.6) |
| Setting of first opioid administration | ||||
| Stepdown unit/ward | 6.7 (6.3 to 7.0) | Reference | 8.5(8.1 to 8.9) | Reference |
| ED | 6.6 (6.1 to 7.1) | −0.1 (−0.6 to 0.4) | 8.4 (7.8 to 8.9) | −0.1 (−0.7 to 0.4) |
| ICU | 7.1 (6.3 to 8.0) | 0.4 (−0.4 to 1.3) | 8.9 (7.9 to 9.8) | 0.4 (−0.6 to 1.3) |
| PACU/procedure unit | 6.7 (6.2 to 7.2) | 0.0 (−0.5 to 0.5) | 8.7 (8.1 to 9.3) | 0.2 (−0.4 to 0.8) |
| Any inpatient use of nonopioid analgesic | ||||
| None | 6.6 (6.4 to 6.9) | Reference | 8.5 (8.2 to 8.8) | Reference |
| ≥1 time during stay | 7.0 (6.6 to 7.4) | 0.4 (0.0 to 0.8) | 8.9 (8.4 to 9.3) | 0.4 (−0.1 to 0.8) |
ED = emergency department; ICU = intensive care unit; PACU = postanesthesia care unit.