Table 1.
Baseline sample characteristics
| Variable | Total (n = 60) | Li/VPA (n = 33) | Li/CBZ (n = 27) | P value |
|---|---|---|---|---|
| Female, n (%) | 40 (66.7%) | 26 (78.8%) | 14 (51.8%) | 0.05 * |
| Age, mean (standard deviation (SD), range) | 27.8 (5.1, 18–35) | 27.5 (4.7, 18–35) | 28.3 (5.7, 18–33) | 0.57 ** |
| Age at illness onset, mean (SD, range) | 20.4 (6.9, 5–35) | 20.0 (7.1, 5–30) | 20.9 (6.7, 13–5) | 0.72 ** |
| Weight in kg, mean (SD) | 71.3 (14.4) | 73.2 (14.1)) | 0.09 * | |
| Current mood, n (%) | ||||
| Depression | 27 (45.0%) | 13 (39.4%) | 14 (51.9%) | 0.57 ** |
| Mania/hypomania | 17 (28.3%) | 11 (33.3%) | 6 (22.2%) | |
| Mixed state | 16 (26.7%) | 9 (27.3%) | 7 (25.9%) | |
| Clinical Global Impressions Scale modified for use in BP, mean (SD, range) | ||||
| Overall | 3.8 (1.1, 1.0–6.0) | 3.8 (1.1, 2.0–6.0) | 3.8 (1.0, 1.0–6.0) | 0.84 ** |
| Depression | 3.3 (1.6, 0.0–6.0) | 3.2 (1.5, 0.0–6.0) | 3.4 (1.8, 0.0–6.0) | 0.62 ** |
| Mania/hypomania | 2.8 (1.6, 1.0–6.0) | 3.2 (1.7, 1.0–6.0) | 2.4 (1.3, 1.0–5.0) | 0.07 ** |
| Manic symptoms (Young Mania Rating Scale) scores, mean (SD, range) | 20.4 (7.2) (5.0–39.0) | 19.3 (7.1, 8.0–35.0) | 21.6 (7.3, 5.0–39.0) | 0.22 ** |
| Depressive symptoms (Hamilton Depression Rating Scale), mean (SD, range) | 11.3 (5.9, 2.0–28.0) | 11.5 (6.0, 2.0–24.0) | 11.1 (5.9, 4.0–28.0) | 0.81 ** |
Li/VPA: lithium plus valproic acid group
Li/CBZ: lithium plus carbamazepine group
*Determined by the Fisher exact test.
**Determined by the student t test.