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. 2019 Oct 26;15:371. doi: 10.1186/s12917-019-2122-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — IL-1β (a), TNF-α (b), IL-2 (c) and IL-10 (d) concentration in the sera of the experimental and control calves post the treatment. NC, negative control; PC, positive control; E1, group received enrofloxacin alone; E2, group received enrofloxacin combined with flunixin meglumine; E3, group received enrofloxacin combined with flunixin meglumine and pegbovigrastim; 1, 2, 3 Id – the 1st, 2nd and 3rd infecting dose of M. bovis; Th – day of therapy starting; a, P < 0.05 between groups PC and NC b, P < 0.05 between groups E1 and NC; c, P < 0.05 between groups E2 and NC; d, P < 0.05 between groups E3 and NC