Table 3.
Changes in AE-QoL total score to identify “improvement” (decrease in PGA-QoL score of ≥1) and “worsening/stable” (increased or unchanged PGA-QoL score)
| Changes in AE-QoL total score | Sensitivity (%) (patients correctly classified as worsening/stable) | Specificity (%) (patients correctly classified as improvement) | Accuracy (%) (proportion of correctly classified patients) |
|---|---|---|---|
| 5 | 64.3% | 76.7% | 68.6% |
| 6 | 73.2% | 76.7% | 74.4% |
| 7 | 73.2% | 76.7% | 74.4% |
| 8 | 75.0% | 70.0% | 73.3% |
| 9 | 78.6% | 70.0% | 75.6% |
| 10 | 78.6% | 70.0% | 75.6% |
| AUC | 0.81 (0.72–0.91) | ||
Abbreviations: AE-QoL, Angioedema quality of life; PGA-QoL, Patient global assessment quality of life; AUC, Area under the curve