Table 2.

ANOVA results of process variables against TPC, TFC, TAC, anti-S. aureus, and anti-S. enterica activity responses.

Responses	Regression	Sum of square	F value	p value	R 2	R adjusted 2
TPC	Linear	1347.15	24.51	0.002∗	98.39	95.48
	Quadratic	3735.17	67.96	0.000∗∗
	Interaction	501.60	9.13	0.018∗
	Total model	5583.92	33.87	0.001∗∗
TFC	Linear	76.072	3.24	0.079	89.26	72.92
	Quadratic	228.990	9.75	0.016∗
	Interaction	20.225	0.86	0.119
	Total model	325.287	4.62	0.043∗
TAC	Linear	69.208	4.25	0.048∗	86.41	71.95
	Quadratic	37.531	2.94	0.078
	Interaction	28.690	5.42	0.031∗
	Total model	135.429	3.53	0.049∗
S. aureus	Linear	0.022	2.18	0.153	97.98	94.33
	Quadratic	3.561	78.07	0.000∗∗
	Interaction	0.094	2.08	0.222
	Total model	3.678	26.88	0.001∗∗
S. enterica	Linear	0.001	1.77	0.215	97.92	94.17
	Quadratic	0.718	71.08	0.000∗∗
	Interaction	0.072	7.17	0.029∗
	Total model	0.809	26.13	0.001∗∗

^∗ p=0.05; ^∗∗p=0.001; ^∗∗∗p < 0.001.