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. 2019 Oct 13;2019:9480945. doi: 10.1155/2019/9480945

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Copyright © 2019 Hai-tao Xiao et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of QD on body loss (a), DAI (b), colon length (c), and histopathological changes (d, e) of mice with DSS-induced colitis. Colitis was induced in all groups except the control group. QD and SASP were administered to mice from days 6 to 12. The change in body weight was taken as the difference between the body weight before the induction of colitis and that immediately before sacrifice on day 13. The DAI was determined by combining the scores for (1) body weight loss, (2) stool consistency, and (3) stool blood. On day 13, the mice were sacrificed, their colon length was measured, and the colonic tissue damage was evaluated by histopathological analysis (H&E staining). Data were expressed as mean ± SD (n = 6–8). ^###p < .001, compared with the control group; ^∗p < .05, ^∗∗p < .01, and ^∗∗∗p < .001, compared with the DSS model group.