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. 2019 Oct 14;2019:4010764. doi: 10.1155/2019/4010764

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Copyright © 2019 Xiang Kong et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of LEGLTBC silencing on rat pancreatic islets. (a) Downregulation of LEGLTBC using siRNA for 48 h and the expression of LEGLTBC in HG/PA-treated rat islets assessed by qRT-PCR analysis. (b) The expression of miR-34a in HG/PA-treated rat islets was assessed by qRT-PCR analysis. Rat pancreatic islets transfected with si-NC or si-LEGLTBC were treated with HG/PA, followed by the detection of SIRT1 and cleaved caspase 3 expression (c, d, and e) and ROS production (f). Results are presented as means ± SD of n = 3‐4 independent experiments. ^∗Conditions significantly different (P < 0.05).