Table 2.
Enrichment analysis of GO and KEGG pathway of DEGs in HCC.
| Category | ID | Term | Count | P-Value |
|---|---|---|---|---|
| BP | GO:0051301 | Cell division | 69 | 7.33E−33 |
| BP | GO:0007062 | Sister chromatid cohesion | 32 | 1.74E−21 |
| BP | GO:0006260 | DNA replication | 36 | 1.34E−19 |
| BP | GO:0007067 | Mitotic nuclear division | 43 | 2.58E−18 |
| BP | GO:0006270 | DNA replication initiation | 16 | 2.17E−14 |
| BP | GO:0000082 | G1/S transition of the mitotic cell cycle | 24 | 2.84E−13 |
| BP | GO:0007077 | Mitotic nuclear envelope disassembly | 15 | 9.00E−11 |
| BP | GO:0031145 | Anaphase-promoting complex-dependent catabolic process | 18 | 8.02486E−10 |
| BP | GO:0016925 | Protein sumoylation | 21 | 1.94799E−09 |
| BP | GO:0000070 | Mitotic sister chromatid segregation | 11 | 3.5016E−09 |
| CC | GO:0005654 | Nucleoplasm | 244 | 4.34338E−55 |
| CC | GO:0005829 | Cytosol | 213 | 2.65555E−26 |
| CC | GO:0005634 | Nucleus | 282 | 9.30863E−22 |
| CC | GO:0005737 | Cytoplasm | 266 | 1.12033E−18 |
| CC | GO:0016020 | Membrane | 143 | 3.98244E−17 |
| CC | GO:0000777 | Condensed chromosome kinetochore | 25 | 2.062E−16 |
| CC | GO:0000776 | Kinetochore | 24 | 4.34306E−16 |
| CC | GO:0005635 | Nuclear envelope | 30 | 2.45558E−14 |
| CC | GO:0005730 | Nucleolus | 68 | 1.1857E−11 |
| CC | GO:0000775 | Chromosome, centromeric region | 17 | 1.72914E−11 |
| MF | GO:0005515 | Protein binding | 452 | 1.69289E−45 |
| MF | GO:0044822 | poly(A) RNA binding | 96 | 1.64645E−17 |
| MF | GO:0005524 | ATP binding | 107 | 3.67235E−14 |
| MF | GO:0003682 | Chromatin binding | 38 | 1.15215E−08 |
| MF | GO:0019901 | Protein kinase binding | 37 | 1.32909E−08 |
| MF | GO:0042393 | Histone binding | 15 | 5.49717E−05 |
| MF | GO:0004674 | Protein serine/threonine kinase activity | 29 | 6.35606E−05 |
| MF | GO:0003777 | Microtubule motor activity | 12 | 6.59963E−05 |
| MF | GO:0051082 | Unfolded protein binding | 14 | 7.41926E−05 |
| MF | GO:0003678 | DNA helicase activity | 7 | 0.000106899 |
| KEGG pathway | hsa04110 | Cell cycle | 35 | 2.22E−19 |
| KEGG pathway | hsa03030 | DNA replication | 15 | 6.16E−11 |
| KEGG pathway | hsa00240 | Pyrimidine metabolism | 16 | 1.70E−05 |
| KEGG pathway | hsa03013 | RNA transport | 21 | 2.97E−05 |
| KEGG pathway | hsa04114 | Oocyte meiosis | 15 | 2.00E−04 |
| KEGG pathway | hsa04115 | p53 signaling pathway | 11 | 4.22E−04 |
| KEGG pathway | hsa03420 | Nucleotide excision repair | 9 | 6.48E−04 |
| KEGG pathway | hsa03040 | Spliceosome | 15 | 0.001273995 |
| KEGG pathway | hsa03430 | Mismatch repair | 6 | 0.002244294 |
| KEGG pathway | hsa03022 | Basal transcription factors | 8 | 0.002420268 |