Table 1.

Biological Activity of Cannabinoids

No	Compound	Oxytosis (EC50)	Energy Loss (EC50)	AβToxicity (EC50)	Trophic Withdrawal (EC50)	Inflammation (EC50)
1	9ΔTHCA	8 μM	20 μM	-	-	>10 μM
2	CBDA	>10 μM	500 nM	70 nM	120 nM	>10 μM
3	CBGA	-	-	-	-	9 μM
4	9ΔTHC	550 nM	500 nM	100 nM	430 nM	7 μM
5	DMCBD	-	-	>1 μM	>5 μM	9 μM
6	CBDV	1.1 μM	90 nM	100 nM	350 nM	>10 μM
7	8ΔTHC	400 nM	60 nM	85 nM	275 nM	>10 μM
8	CBG	1.9 μM	2 μM	80 nM	>1.5 μM	>10 μM
9	CBC	750 nM	750 nM	100 nM	200 nM	>10 μM
10	CBN	700 nM	300 nM	90 nM	120 nM	>10 μM
11	CBD	610 nM	200 nM	30 nM	75 nM	10 μM

EC₅₀ = 50% of maximal protection; Oxytosis and Energy Loss use HT22 cells; Aβ Toxicity uses MC65 cells; Trophic Withdrawal uses primary neurons; Inflammation uses BV2 microglia. THCA, tetrahydrocannabinol acid; CBDA, cannabidiolic acid; CBGA, cannabigerolic acid; Δ⁹THC; CBD, cannabidiol; CBDV, cannabidivarin, Δ⁸THC; CBG, cannabigerol; CBC, cannabichromene; CBN, cannabinol; DMCBD, dimethyl cannabidiol. Toxicity at 10 μM is indicated by -. EC₅₀s below 1 μM are shaded in grey.