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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: J Pediatr. 2019 Aug 9;214:96–102. doi: 10.1016/j.jpeds.2019.07.041

Figure 3.

Figure 3.

Changes in normalized cerebral blood flow velocity (normalizedCBFV) in control (top panel) and POTS patients with OI (bottom panel) during imposition of a controlled orthostatic challenge using LBNP following no treatment (No TX – white bars), IV saline (Saline – gray bars) and ingestion of oral rehydration solution (ORS – black bars). Because there was no pressure effect, the comparisons reflect the combined effect (i.e., the weighted average) of the CBVv in the ORS group vs. No Tx. In controls, normalized CBFv was not significantly reduced at −45 mmHg, nor did fluid administration result in any significant change. In POTS, CBFv following ORS was significantly higher than No TX (ǂ = p<0.0005), which was independent of pressure.