Table 2.

Clinicopathologic Factors Associated with Overall Survival in R0/R1 Resections

Variable	Univariable Cox regression		Multivariable Cox regression
	HR (95% CI)	p Value	HR (95% CI)	p Value
Age, y	1.02 (1.01-1.03)	<0.01*	1.02 (1.01-1.03)	<0.01*
Sex
Male	Reference
Female	1.06 (0.85-1.34)	0.60
Race
White	Reference
African American	1.05 (0.73-1.51)	0.78
Other	0.90 (0.61-1.33)	0.60
Primary location
Truncal/extremity	Reference		Reference
Retroperitoneal	0.64 (0.48-0.83)	<0.01*	1.32 (0.97-1.80)	0.08
Tumor size
< 5 cm	Reference		Reference
5-10 cm	1.79 (1.156-2.77)	<0.01*	1.38 (0.87-2.18)	0.11
> 10 cm	3.03 (1.98-4.62)	<0.01*	2.13 (1.36-3.34)	<0.01*
Histopathology
UPS/malignant fibrous histiocytoma	0.86 (0.68-1.10)	0.23
Leiomyosarcoma	1.06 (0.75-1.49)	0.74
Myxofibrosarcoma	0.81 (0.51-1.29)	0.37
Liposarcoma, dedifferentiated	1.29 (0.79-2.11)	0.31
Synovial	0.79 (0.46-1.35)	0.39
Liposarcoma, pleomorphic	1.16 (0.73-1.85)	0.53
Other	1.18 (0.92-1.51)	0.20
Lymph node metastasis
Negative	Reference
Positive	2.61 (1.37-4.98)	<0.01*
Lymphovascular invasion
Absent	Reference
Present	1.94 (1.25-3.03)	<0.01*
Final margin status
Negative (R0)	Reference		Reference
Positive (R1)	1.64 (1.25-2.15)	<0.01*	1.79 (1.34-2.39)	<0.01*
Multimodal treatment
Radiation	0.79 (0.63-0.99)	0.04*	0.75 (0.58-0.96)	0.11
Chemotherapy	0.91 (0.72-1.16)	0.44
Recurrence
No recurrence	Reference		Reference
Recurrence	7.1 (5.22-9.66)	<0.01*	-	-
Lung metastasis	3.91 (3.11-4.92)	<0.01*	4.26 (3.28-5.53)	<0.01*
Lung surveillance modality
CXR	Reference		Reference
CT	1.61 (1.17-2.21)	<0.01*	1.01 (0.71-1.43)	0.97

^*Significant.

CXR, chest x-ray; HR, hazard ratio; UPS, undifferentiated pleomorphic sarcoma.