Table 1.

IGNITE inclusion and exclusion criteria.

Inclusion Criteria

Exclusion Criteria

• Men and women 65 – 80 yrs • Ambulatory without pain or the use of assisted walking devices • Able to speak and read English • Medical clearance by primary care physician (PCP) • Living in community for duration of the study • Reliable means of transportation • No diagnosis of a neurological disease • Eligible to undergo MRI • Telephone Interview of Cognitive Status9 score >25 • Cognitive adjudication decision of cognitively normal

• Current diagnosis of an Axis I or II disorder including Major Depression • History of major psychiatric illness including schizophrenia (not including general anxiety disorder or depression (Geriatric Depression Scale [GDS] ≥9)10 • Current treatment for cancer – except non-melanoma skin cancer • Neurological condition (MS, Parkinson’s, Dementia) or brain injury (Stroke) • Type I Diabetes, Insulin-dependent Type II Diabetes, uncontrolled Type II diabetes (defined as an HbA1c level > 10) • Current alcohol or substance abuse or treatment for abuse in the past 5 years • Current treatment for congestive heart failure, angina, uncontrolled arrhythmia, deep vein thrombosis (DVT) or another cardiovascular event • Myocardial infarction, coronary artery bypass grafting, angioplasty or other cardiac condition in the past year • Regular use of an assisted walking device • Presence of metal implants (pacemaker, stents) that are MR ineligible • Inability to complete the MRI scan • Claustrophobia • Color Blindness • Not fluent in English • Not medically cleared by PCP • Engaging in >20 minutes of moderate intensity physical activity per day for 3 days or more per week • Not local or able to travel 3 times per week to the exercise facility • Travelling consecutively for 3 weeks or more during the study • Telephone Interview of Cognitive Status9 score <25 • Cognitive adjudication decision of memory impairment • Unwillingness to be randomized to one of the three groups • Current participation in an ongoing trial likely to influence exercise ability or cognitive function (e.g., mindfulness training).