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. 2019 Oct 22;13:3657–3667. doi: 10.2147/DDDT.S217826

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© 2019 Zhu et al.

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OM reduces glomerular hypertrophy and injury in db/db mice. (A–D) Eight-week-old male db/db mice were intragastrically administered with 10 mg/kg OM, 20 mg/kg OM or equal volume of vehicle saline (0 mg/kg OM) per day for 8 weeks (n = 15). The wild-type littermates (WT, n = 15) were administered with equal volume of saline and used as controls for db/db mice. The glomerular tuft area (A), glomerular tuft volume (B), glomerular basement membrane thickness (C), and mesangial matrix fraction (D) were analyzed by the periodic acid-Schiff (PAS) staining on kidney sections. The fibronectin expression (E) in the renal cortex from 5 representative mice in each group was analyzed by Western blotting assay. β-Actin was used as a loading control. The representative images (left) and analysis of fibronectin expression (right) are shown. Data are mean ± SD. *P < 0.05; **P < 0.01.