Table 1.
Demographic and clinical-pathological characteristics in patients with a diagnosis of mixed neuroendocrine non-neuroendocrine neoplasm
| Variable | Category | n (%) | Variable | Category | n (%) |
| Gender | Predominant component | ||||
| Female | 25 (36.2) | NE | 27 (39.1) | ||
| Male | 44 (63.8) | Non-NE | 12 (17.4) | ||
| Equal proportion | 7 (10.1) | ||||
| NA | 23 (33.3) | ||||
| Disease stage | Morphology of NE component | ||||
| Localised | 37 (53.6) | Large cell | 13 (18.8) | ||
| Advanced | 30 (43.5) | Small cell | 5 (7.2) | ||
| NA | 2 (2.9) | Others | 1 (1.4) | ||
| NA | 50 (72.4) | ||||
| Primary tumour site | Grading of NE component | ||||
| Colon | 22 (31.9) | Grade 1 | 3 (4.3) | ||
| Oesophagus/OGJ | 11 (15.9) | Grade 2 | 14 (20.3) | ||
| Rectum | 8 (11.6) | Grade 3 | 57 (82.6) | ||
| Small bowel/ICJ | 8 (11.6) | NA | 3 (4.3) | ||
| Pancreas | 6 (8.7) | ||||
| Stomach | 4 (5.8) | Ki-67 of NE component | |||
| Anus | 4 (5.8) | Median | 70% (55-68) | ||
| Biliary tract | 3 (4.3%) | < 55% | 19 (27.5) | ||
| Appendix | 2 (1.9) | ≥ 55% | 37 (53.6) | ||
| Unknown | 1 (1.5) | NA | 13 (18.8) | ||
| Histology of non-NE component | |||||
| Lower GI | 4 (63.8) | ADC | 51 (39.1) | ||
| Upper GI | 15 (21.7) | Adenoma | 2 (17.4) | ||
| PB | 9 (13) | Carcinoma/SCC | 1 (10.1) | ||
| Unknown | 1 (1.5) | NA | 15 (33.3) | ||
| Lower GI | 4 (63.8) | ||||
| Grading of non- NE component | |||||
| Grade 1 | 10 (14.5) | ||||
| Grade 2 | 14 (20.3) | ||||
| Grade 3 | 20 (29.0) | ||||
| Adenoma | 2 (17.4) | ||||
| NA | 23 (33.3) |
Note: the sum of the percentages might not reach 100% due to rounding. ECOG: Eastern Cooperative Oncology Group; PS: Performance status; Loc: Localised stage; Adv: Advanced stage; NE: Neuroendocrine; ADC: Adenocarcinoma; SCC: Squamous cell carcinoma; OE: Oesophageal; OGJ: Oesophago-gastric junction; ICJ: Ileo-caecal junction; Lower GI: Lower gastrointestinal tract; Upper GI: Upper gastrointestinal tract; PB: Pancreatico-biliary tract; NA: Not available.