Table 4.

Univariate analysis of progression-free survival and overall survival in patients with advanced mixed neuroendocrine non-neuroendocrine neoplasm

	PFS				OS
	n	Median (mo)	95%CI	P value	n	Median (mo)	95%CI	P value
Primary tumour site
Lower GI	35	6.6	4.6-7.4	0.008	37	9.6	5.21-15.2	< 0.001
PB	7	4.4	0.8-NR		7	4.4	2-NR
Upper GI	11	9.5	5.1-NR		11	9.5	5.1-NR
Unknown	1	1.3	-		1	1.3	-
Age at diagnosis
< 70 yr	32	5.9	4.3-9.5	0.19	32	9.5	5.2-16.3	0.23
≥ 70 yr	22	5.6	3.8-8.0		22	9.0	4.6-14.7
ECOG PS
0-1	36	6.9	4.6-8.2	0.9	36	9.6	5.216.3	0.45
≥ 2	13	5.9	3.4-NR		13	5.9	4.6-NR
Gender
Female	20	5.2	2.6-9.1	0.5	20	7.9	3.7-19.8	0.96
Male	34	6.9	4.6-9.5		34	9.0	5.2-15.2
Predominant component
ADC	11	4.4	2.6-NR	0.08	11	4.4	2.6-NR	0.14
EQUAL	6	9.5	4.4-NR		6	34.2	12.4-NR
NE	23	5.6	4.3-7.2		23	7.2	5.2-13.7
Grading NE component
G1	0				0
G2	5	6.9	5.2-NR	0.65	5	53.8	5.2-NR	0.34
G3	49	5.6	4.4-7.4		49	9.0	5.2-13.4
Ki-67 of NE component
< 55%	14	7.0	5.3-12.9	0.78		10.7	5.6-NR	0.6
≥ 55%	32	4.7	3.9-8.0			7.2	5.15-13.4
First line active treatment
No	13	2.2	1.6	< 0.001		3.7	2.0	< 0.001
Yes	40	7.1	5.2-9.8			13.4	9.0-16.3

Note: Advanced mixed neuroendocrine non-neuroendocrine neoplasms include both patients who presented with advanced disease at diagnosis and those who developed advanced recurrent disease after initial curative treatment. CT: Chemotherapy; RT: Radiotherapy; BSC: Best supportive care; neoadj: Neoadjuvant; adj: Adjuvant; periop: Perioperative; fluop: Fluopyrimidine; etop: Etoposide; plat: Platinum; epi: Epirubicin; iri: Irinotecan; gem: Gemcitabine; mAB: Monoclonal antibody; NA: Not available.