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. 2019 Sep 9;23(11):7830–7843. doi: 10.1111/jcmm.14662

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© 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The impact of OPA1 knockout on mitochondria injury and apoptosis in vitro. A and B, Western blot assay of mitochondrial fission‐, fusion‐ and mitophagy‐related proteins in H/R myocytes with PD150606 and OPA1 siRNA pretreatment in vitro and quantitative analyses. C‐E, Mitochondrial morphology was observed using MitoTracker Green staining, plus the index of fragmentation and length was analysed. The scale of the mitochondrial images is 10 µm. F and G, Cellular apoptosis was detected by flow cytometry in H/R myocytes with PD150606 and OPA1 siRNA pretreatment in vitro and quantitative analysis. Data are means ± SD from at least three different experiments. *P < .05, **P < .01