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A, Stimulating GPCRs promotes signal transduction through the cAMP pathway via specific extracellular ligands leading to the activation of AC, which converts ATP into cAMP. AKAP anchors in PKA. B, cAMP binding to the R subunits of PKA increases, and the active catalytic subunits are released to phosphorylate their targets. C, This compact state may provide for the phosphorylation of associated target proteins
