. 2019 Sep 11;23(11):7170–7179. doi: 10.1111/jcmm.14659

Table 1.

Characterization of AKAPs in cardiomyocytes

Function	Gene Name	Alternative Name	Binding Partners	Intracellular Localization	References
Pro‐hypertrophic	AKAP6	mAKAP	PKAII, PDE4D3, AC5, RyR2, CaNA, PP2A, NFATc, ERK5, MEK5, Epac1, Rap1, Siah2, PDK1, RSK3, NCX1, nesprin‐1α,	Nuclear envelope	1, 2, 38, 39, 40, 41, 42, 43, 44, 45, 46, 96, 97, 98
Pro‐hypertrophic	AKAP13	AKAP‐Lbc, Ht31	PKA RII, RhoA, Actin, PKC, PKD, KSR1, Raf, MEK1/2, ERK1/2, PKNα	Cytoskeleton	1, 31, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 99, 100
Anti‐hypertrophic	AKAP7	AKAP15, AKAP18	PKAII, L‐type Ca²⁺ channel, phospholamban, PP1, inhibitor 1	Plasma membrane, endoplasmic reticulum	1, 4, 59, 60, 61, 62, 63, 101
	AKAP1	D‐AKAP1, AKAP121, AKAP149	PKAI and II, PKCα, Src, RSK1, PP1, PP2A, CaN, PTPD1, Lfc	Mitochondria, nuclear envelope, endoplasmic reticulum	1, 2, 35, 36, 37, 102, 103, 104
	AKAP5	AKAP79, AKAP150	PKAII, PKC, CaN, KCNQ2, L‐type Ca²⁺ channel, β‐AR, AC5 and AC‐6, SAP97, caveolin‐3	Plasma membrane, T tubules	1, 2, 3, 22, 28, 65, 66, 67, 84, 85, 86, 87, 105, 106
Contractility	AKAP5	AKAP79, AKAP150	PKAII, PKC, CaN, KCNQ2, L‐type Ca²⁺ channel, β‐AR, AC5 and AC‐6, SAP97, caveolin‐3	Plasma membrane, T tubules	1, 2, 3, 22, 28, 65, 66, 67, 84, 85, 86, 87, 105, 106
Contractility	AKAP12	Gravin, AKAP250	PKA RII, β‐AR, PKC, PDE4D, Src	Plasma membrane	1, 2, 80, 81, 82, 83, 107, 108
Arrhythmias	AKAP9	Yotiao, AKAP350, AKAP450	PKAII, PP1, PP2A, PKC, PKN1, kinase 1, AC, PDE4D3, KCNQ1, CLIC	Plasma membrane, Golgi, centrosome	1, 2, 3, 84, 85, 86, 87, 88, 109, 110
Arrhythmias	AKAP5	AKAP79, AKAP150	PKAII, PKC, CaN, KCNQ2, L‐type Ca²⁺ channel, β‐AR, AC5 and AC‐6, SAP97, caveolin‐3	Plasma membrane, T tubules	1, 2, 3, 22, 28, 65, 66, 67, 84, 85, 86, 87, 105, 106