Figure 3.

SNHG16 knockdown inhibits in vivo tumour growth of DLBCL cells. A, OCI‐LY7 cells that were transfected with lentivector‐mediated SNHG16 shRNA or non‐targeting (NT) shRNA were subcutaneously implanted into NOD/SCID mice. The volume of tumours initiated by OCI‐LY7 cells with SNHG16 knockdown (n = 4) was significantly reduced compared with the control group (n = 4). B, The expression of SNHG16 was markedly lower in xenograft tumour tissues collected from SNHG16 knockdown group (n = 4) than the control group (n = 4). C, Immunoblotting analysis indicated that the levels of PCNA and Bcl‐2 protein were significantly lower in xenograft tumour tissues collected from the SNHG16 knockdown group (n = 4) than the control group (n = 4). *P < .05