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. 2019 Sep 9;23(11):7342–7348. doi: 10.1111/jcmm.14593

Figure 4.

Figure 4

LINC01303/miR‐101‐3p/EZH2 signalling regulates GC progression. A, miR‐101‐3p‐binding sequences in LINC01303 or the 3′‐UTR of EZH2 and mutant sites in LINC01303 or the 3′‐UTR of EZH2. B, C, Luciferase reporter assay showed that the luciferase activity of either LINC01303‐WT or EZH2 3′‐UTR‐WT was inhibited by miR‐101‐3p mimics. D, miR‐101‐3p expression was increased in BGC823 cells after LINC01303 silencing. E, F, EZH2 expression was reduced after transfection with miR‐101‐3p mimics. G, H, LINC01303 regulated EZH2 expression in BGC823 cells through inhibitor miR‐101‐3p. I, The expression of LINC01303 was negatively correlated with miR‐101‐3p expression in GC tissues. J, EZH2 expression was reversely correlated with miR‐101‐3p level in GC tissues. K, Expression of EZH2 was measured in BGC823 cells after transfection with described vectors. L, CCK8 assay was used to analyse cell proliferation. M, N, Transwells assay was exploited to measure migration and invasion in BGC823 cells. The data represent the mean ± SD from three independent experiments. *P < .05. **P < .01, ***P < .001