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Publication bias judged by the Deek’s funnel plot for the diagnostic meta-analysis. A-C: Begg’s test for the down-regulated and up-regulated circular RNA (circRNA) signatures in predicting the overall survival in hepatocellular carcinoma; D: The trim and fill method performed to assess the possible effects of bias on the overall pooled effects of the up-regulated circRNA signature. The hollow circles in squares indicate the imputed studies.
