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DOX inhibits lymphatic contractions in isolated rat mesenteric lymph vessels. (A) Rhythmic contractions of a control lymph vessel in physiologic salt solution. (B) In another lymph vessel, increasing concentrations of DOX (0.5–20 μmol/l) progressively inhibited rhythmic contractions and reduced end-diastolic diameter. (C) A subset of lymph vessels exposed to DOX were returned to drug-free PSS, which reversed the inhibitory effect of DOX on rhythmic contractions.
