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. 2019 Nov;371(2):278–289. doi: 10.1124/jpet.119.257592

Fig. 2.

Fig. 2.

DOX reduces end-diastolic diameter, contraction frequency and amplitude, and calculated flow in isolated rat mesenteric lymph vessels. Lymph vessels were exposed either to drug-free PSS (control) or to increasing concentrations of DOX (0.5–20 μmol/l). Data from lymph vessels exposed to DOX and control vessels exposed to PSS were compared at the same time point for statistical analysis. In 12 lymph vessels, (A) DOX progressively decreased EDD and (B) the amplitude of rhythmic contractions (n = 12), and these effects were partially reversed after washout of DOX (n = 8). Likewise, (C) contraction frequency and (D) calculated flow were significantly reduced by DOX compared with PSS control (n = 12), and these effects also were at least partially reversed after washout of DOX (n = 8). Data reported as mean ± S.E.M. analyzed using two-way ANOVA with Holm-Sidak post-test (n = 12; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001).