TABLE 1.

DOX reduces end-diastolic diameter, contraction frequency, and amplitude, and calculated flow in isolated rat mesenteric lymph vessels

Exposure of lymph vessels to increasing concentrations of DOX (0.5–20 μmol/l) progressively decreased EDD, contraction frequency, amplitude, and calculated flow (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; mean ± S.E.M., n = 12). These effects were partially reversed after washout of DOX (†P < 0.05; mean ± S.E.M., n = 8).

DOX	EDD	Frequency	Amplitude	Flow
μM	% Baseline
0.5	99.6 ± 0.4	99.7 ± 5.2	99.3 ± 1.9	101.9 ± 5.5
1	98.1 ± 0.8	96.3 ± 5.3	96.9 ± 2.4	92.2 ± 4.7
2	95.5 ± 1.4	102.7 ± 5.7	86.9 ± 4.4	86.6 ± 6.5
5	91.2 ± 3.3	86.7 ± 9.0	75.4 ± 5.9	67.2 ± 9.4
10	83.8 ± 4.5*	60.9 ± 11.5	54.9 ± 9.4**	35.1 ± 10.1***
20	75.8 ± 5.3****	44.6 ± 12.0	27.9 ± 8.4****	24.2 ± 7.7**
Washout	95.1 ± 2.2	91.7 ± 8.5†	69.3 ± 7.8†	75.5 ± 9.6†