TABLE 3.

An intravenous push infusion of DOX disrupts lymph flow in rat mesenteric lymph vessels in vivo

Compared with saline, systemic administration of DOX significantly and persistently decreased positive volumetric flow (*P < 0.05; **P < 0.01; ***P < 0.001; mean ± S.E.M., n = 8).

Time (min)	intravenous SAL	intravenous DOX 10 mg/kg
10	117.9 ± 15.1	79.8 ± 12.4
15	102.2 ± 14.2	86.3 ± 9.4
20	111.1 ± 13.8	79.0 ± 5.9
25	119.1 ± 16.2	67.9 ± 5.8*
30	122.9 ± 10.9	69.2 ± 6.4*
35	109.8 ± 13.7	63.4 ± 11.0
40	120.3 ± 13.7	60.9 ± 11.9*
45	107.7 ± 15.0	53.8 ± 13.3*
50	111.8 ± 17.9	49.3 ± 10.7*
55	121.2 ± 11.9	40.3 ± 6.0***
60	116.6 ± 11.1	48.4 ± 7.7**
65	124.4 ± 21.2	46.4 ± 11.1***
70	123.4 ± 18.6	44.8 ± 10.1***
75	105.9 ± 16.2	49.3 ± 10.8*
80	126.7 ± 8.9	47.6 ± 9.4***
85	113.3 ± 7.0	54.3 ± 13.2*
90	99.5 ± 13.5	55.8 ± 15.5
95	125.5 ± 23.6	49.4 ± 16.5***
100	90.1 ± 18.0	56.3 ± 18.2