TABLE 4.
Effect of DOX and RYR block on [Ca2+i], rhythmic contractions, and calculated flow in isolated lymph vessels
Compared with baseline values, DOX (10 μmol/l) increased resting [Ca2+i], reduced end-diastolic diameter, and decreased contraction amplitude, resulting in attenuation of flow. Block of RYRs by a high concentration of ryanodine (100 μmol/l) prevented the effects of DOX (*P < 0.05; mean ± S.E.M., n = 4–7).
| PSS | DOX | RYR Block + DOX | |
|---|---|---|---|
| Resting [Ca2+i] | 103.1 ± 5.3 | 123.1 ± 11.5* | 96.5 ± 4.6 |
| EDD | 99.4 ± 1.9 | 93.9 ± 2.7* | 102.9 ± 1.5 |
| Amplitude | 97.1 ± 5.6 | 75.9 ± 7.9* | 116.4 ± 13.7 |
| Frequency | 100.9 ± 1.5 | 100.7 ± 4.8 | 88.4 ± 13.9 |
| Flow | 98.7 ± 4.6 | 75.2 ± 8.9* | 102.9 ± 15.3 |