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. 2019 Sep 20;9(23):6824–6839. doi: 10.7150/thno.36739

Figure 6.

Figure 6

Proof-of-principle fluorescence-guided surgery studies with multimodal 68Ga-IRDye800CW-PSMA-11 in tumor-bearing mice and healthy pigs. (A) 68Ga-IRDye800CW-PSMA-11 (0.5 nmol) was injected in s.c. LNCaP tumor-bearing mice for small-animal PET imaging, followed by ex vivo fluorescence detection 2 h p.i. (IMAGE1 S system). (B) After preimaging acquisition of background fluorescence (da Vinci FireFly system), IRDye800CW-PSMA-11 (30 μg/kg) was injected i.v. in healthy pigs. 1 h p.i. fluorescence-guided prostatectomy using in vivo and ex vivo fluorescence detection was performed. This research was originally published in JNM, Baranski et al., PSMA-11-Derived Dual-Labeled PSMA Inhibitors for Preoperative PET Imaging and Precise Fluorescence-Guided Surgery of Prostate Cancer, J Nucl Med, 2017, © SNMMI 54.