Skip to main content
. 2019 Sep 19;9(23):6797–6808. doi: 10.7150/thno.36375

Figure 7.

Figure 7

Schematic illustration of identification of fibrogenic fibroblasts with IR-780. In fibroblasts, HIF-1α regulates the expression of SLCO2A1, which mediates the uptake of IR-780. In another aspect, HIF-1α regulates the expression of glycolysis related enzymes including LDHA, LDHB, LDHC, which further mediates the glycolysis in fibroblasts. In fibrogenic fibroblasts, the expression of HIF-1α is high, which induces high glycolysis and high expression of SLCO2A1, and further mediates increased accumulation of IR-780.