Figure 7.
Inhibition of IGF1/PI3K/AKT pathway attenuates the in vivo effects of ES-EVs on senescent MSCs. (A) The fate of MSCs after transplantation was tracked by molecular imaging. Images were from representative animals receiving 5×105 MSCs with F12, ES-EVs, or ES-EVs and PPP. (B) Quantitative analysis of BLI signals. (C) Analysis of the wound-healing area at different time points (left). Quantitative analysis of wound-healing area (right). (D) Histologic analysis of wound area by HE staining. Scale bar represents 50um. Data are presented as the Mean ± SEM. (n = 3; *p <.05).