. Author manuscript; available in PMC: 2019 Oct 28.

Published in final edited form as: J Clin Monit Comput. 2018 Dec 11;33(5):795–802. doi: 10.1007/s10877-018-0234-0

Table 1.

Performance criteria for closed-loop vasopressor controller in stable sepsis simulation scenarios with differing norepinephrine pharmacodynamics

Norepinephrine response level	MDPE (%)	MDAPE (%)	Wobble (%)	Divergence (%) m⁻¹	Oscillation (cycles h⁻¹)	Oscillation amplitude (mmHg)
0.1 ×	1.0	1.2	0.5	− 7.1	-	-
0.2 ×	0.9	1	0.6	− 4.6	-	-
0.5 ×	0.7	0.8	0.4	− 2.3	-	-
1 ×	0.7	0.7	0.3	− 1.2	-	-
2 ×	0.6	0.7	0.4	− 1	-	-
5 ×	0.7	0.7	0.4	− 0.3	-	-
10 ×	1.2	1.2	1.0	− 0.1	18–22	4

MDPE median performance error, MDAPE median absolute performance error; definitions (including wobble and divergence) found in Varvel et al. [30]

Oscillation and Oscillation Amplitude—the frequency of cycling of the MAP around the target, and the total pressure change (maximum–minimum) during a cycle