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. 2019 Oct 23;12:8769–8777. doi: 10.2147/OTT.S197244

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© 2019 Bastos and Antonarakis.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Prostate cancer clinical states model.

Notes: Data created to include the corresponding agents that are FDA approved in each state. Data from Scher et al.³⁵ Green boxes refer to the castration-sensitive state whereas the orange boxes refer to castration-resistant state. Green texts refer to castration-sensitive state whereas orange texts refer to castration-resistant state.

Abbreviations: ADT, androgen deprivation therapy; nmCRPC, non-metastatic castration-resistant prostate cancer; mCRPC, metastatic castration-resistant prostate cancer; MSI-H, microsatellite instability.