Table 2.
List of the five most frequent hubs, their incidence in patients for each cancer type, and their respective cancer hallmark.
| Cancer type | Hub | Number of patients | Percentage of patients | Cancer hallmark | Reference |
|---|---|---|---|---|---|
| STAD | HSP90AB1 | 29 | 90.6% | Genomic instability | (Haase and Fitze, 2016) |
| MYH9 | 27 | 84.3% | Cell adhesion, invasion and migration | (Li and Yang, 2016) | |
| YWHAZ | 22 | 68.7% | Cell proliferation, invasion and migration | (Nishimura et al., 2013; Deng et al., 2019; Hong et al., 2018) | |
| FN1 | 18 | 56.2% | Cell adhesion, invasion and migration, cell growth, cell death escape | (Soikkeli et al., 2010; Wang et al., 2017) | |
| HSPA5 | 14 | 43.7% | Genomic instability | (Haase and Fitze, 2016) | |
| LUAD | YWHAZ | 48 | 84.2% | Cell proliferation, invasion and migration | (Nishimura et al., 2013; Deng et al., 2019; Hong et al., 2018) |
| HSP90AB1 | 46 | 80.7% | Genomic instability | (Haase and Fitze, 2016) | |
| HSPA5 | 38 | 66.6% | Genomic instability | (Haase and Fitze, 2016) | |
| FN1 | 30 | 52.6% | Cell adhesion, invasion and migration, cell growth, cell death escape | (Wang et al., 2017; Soikkeli et al., 2010) | |
| ACTB | 27 | 47.4% | Invasion and migration | (Guo et al., 2013) | |
| LUSC | YWHAZ | 48 | 96.0% | Cell proliferation, invasion and migration | (Nishimura et al., 2013; Deng et al., 2019; Hong et al., 2018) |
| HSP90AB1 | 39 | 78.0% | Genomic instability | (Haase and Fitze, 2016) | |
| HSPA5 | 28 | 56.0% | Genomic instability | (Haase and Fitze, 2016) | |
| TP63 | 25 | 56.0% | Cell growth | (Jiang et al., 2018) | |
| NPM1 | 21 | 44.0% | Invasion and migration, inflammation, genomic instability | (Loubeau et al., 2014; Box et al., 2016; Lin et al., 2016) | |
| LIHC | HSP90AB1 | 41 | 83.6% | Genomic instability | (Haase and Fitze, 2016) |
| HSPB1 | 28 | 57.1% | Genomic instability, cell death escape | (Deng et al., 2019; Hong et al., 2018) | |
| MYH9 | 27 | 55.1% | Cell adhesion, invasion and migration | (Li and Yang, 2016) | |
| ACTB | 24 | 48.9% | Invasion and migration | (Guo et al., 2013) | |
| YWHAZ | 21 | 42.9% | Cell proliferation, invasion and migration | (Nishimura et al., 2013; Deng et al., 2019; Hong et al., 2018) | |
| KIRC | FN1 | 61 | 87.1% | Cell adhesion, invasion and migration, cell growth, cell death escape | (Wang et al., 2017; Soikkeli et al., 2010) |
| RPL10 | 56 | 80.0% | Invasion and migration, cell death escape | (Goudarzi and Lindström, 2016; Shi et al., 2018) | |
| VCAM1 | 55 | 78.6% | Inflammatory response, cell adhesion, cell growth | (Huang et al., 2013; Kong et al., 2018) | |
| NPM1 | 47 | 67.1% | Invasion and migration, inflammation, genomic instability | (Loubeau et al., 2014; Box et al., 2016; Lin et al., 2016) | |
| ACTB | 43 | 61.4% | Invasion and migration | (Guo et al., 2013) | |
| KIRP | ACTB | 25 | 78.1% | Invasion and migration | (Guo et al., 2013) |
| LRRK2 | 20 | 62.5% | Cell proliferation, cell death escape | (Wallings et al., 2015) | |
| VCAM1 | 18 | 56.3% | Inflammatory response, cell adhesion, cell growth | (Huang et al., 2013; Kong et al., 2018) | |
| FN1 | 17 | 53.1% | Cell adhesion, invasion and migration, cell growth, cell death escape | (Soikkeli et al., 2010; Wang et al., 2017) | |
| HSPB1 | 16 | 50.0% | Genomic instability, cell death escape | (Deng et al., 2019; Hong et al., 2018) | |
| BRCA | FN1 | 80 | 95.2% | Cell adhesion, invasion and migration, cell growth, cell death escape | (Wang et al., 2017; Soikkeli et al., 2010) |
| ACTB | 58 | 69.0% | Invasion and migration | (Guo et al., 2013) | |
| YWHAZ | 55 | 65.5% | Cell proliferation, invasion and migration | (Nishimura et al., 2013; Deng et al., 2019; Hong et al., 2018) | |
| HSP90AB1 | 49 | 58.3% | Genomic instability | (Haase and Fitze, 2016) | |
| ESR1 | 44 | 52.3% | Cell proliferation, invasion and migration, escape immune response | (Mostafa et al., 2014; Ahmed and Aboelnaga, 2015; Jeselsohn et al., 2015) | |
| THCA | FN1 | 47 | 83.9% | Cell adhesion, invasion and migration, cell growth, cell death escape | (Wang et al., 2017; Soikkeli et al., 2010) |
| LRRK2 | 41 | 73.2% | Cell proliferation, cell death escape | (Wallings et al., 2015) | |
| FLNA | 39 | 69.6% | Cell adhesion, invasion and migration, growth, cell death escape | (Shao et al., 2016) | |
| RPL10 | 27 | 48.2% | Invasion and migration, cell death escape | (Shi et al., 2018; Goudarzi and Lindström, 2016) | |
| MYH9 | 25 | 44.6% | Cell adhesion, invasion and migration | (Li and Yang, 2016) | |
| PRAD | HSPA5 | 31 | 62.0% | Genomic instability | (Haase and Fitze, 2016) |
| HSP90AB1 | 30 | 60.0% | Genomic instability | (Haase and Fitze, 2016) | |
| RPL10 | 30 | 60.0% | Invasion and migration, cell death escape | (Goudarzi and Lindström, 2016; Shi et al., 2018) | |
| NPM1 | 29 | 58.0% | Invasion and migration, inflammation, genomic instability | (Loubeau et al., 2014; Box et al., 2016; Lin et al., 2016) | |
| NDRG1 | 28 | 56.0% | Invasion and migration, growth | (Menezes et al., 2017) |