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. 2019 Sep 14;6(5):1027–1040. doi: 10.1002/ehf2.12509

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© 2019 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Time‐course effect of statins in human ventricular myofibroblasts de‐differentiation and cellular respiration. (A) Representative immunoblots showing the time‐dependent effect of in vitro treatment of simvastatin (200 nmol/L), and corresponding bar graph depicts significant de‐differentiation from 24 h onwards. (B) Graphical representation of pooled data of time‐dependent effect of simvastatin (200 nmol/L) on OCR of differentiated hVFs. Respective bar graphs depict significant reduction in both basal and ATP‐linked OCRs from 18 h onwards. Data mean ± SD. ^* P < 0.05; one‐way ANOVA.