Figure 1.
Silencing myeloid Acat1 rather than silencing Acat1 globally extends the life span of modified Paigen diet–fed ApoE−/− mice. A, body weights of male ApoE−/−, ApoE−/−/Acat1−M/−M, and ApoE−/−/Acat1−/− mice fed a modified Paigen diet for 20 weeks. B, survival curves of ApoE−/−, ApoE−/−/Acat1−M/−M, and ApoE−/−/Acat1−/− mice.