Figure 2.

Deleting myeloid Acat1 reduces the atherosclerotic burden in ApoE^−/− mice fed a modified Paigen diet for an extended period of time. A, enface staining of whole aortas isolated from ApoE^−/− and ApoE^−/−/Acat1^−M/−M mice treated with modified Paigen diet for 20 weeks. B and D, quantitation of lesion area detected in male (B) and female (C) aortas. D and E, H&E staining of cross-sections of ascending (D) and descending (E) aortas from male ApoE^−/− and ApoE^−/−/Acat1^−M/−M mice. The data are reported as means ± S.E. *, p ≤ 0.05; **, p ≤ 0.01.