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Schematic representation of nongenomic action of E2 on vascular endothelial H2S release. E2 enhances the interaction of membrane estrogen receptor α (ERα) and G α subunit Gαi-2/3, which subsequently transactivates pGC-A to produce cGMP and activates PKG-Iβ. The isoform of active PKG-Iβ interacts with CSE protein, leading to its phosphorylation and rapid endothelial H2S release.
