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. 2019 Sep 4;294(43):15593–15603. doi: 10.1074/jbc.RA119.009697

Scheme 1.

Scheme 1.

A, steady-state kinetics scheme describing a linear mixed-type inhibition system, in which the enzyme (E) is able to bind both the PNP substrate (S) and the PLP product (P) at the same time. B, ping-pong kinetic mechanism of the reaction catalyzed by PNPOx, in which Eo and Er are the oxidized form and reduced form of the enzyme, respectively. The PLP product inhibits the enzyme when it binds to the Eo form.