Table 1.

Failed treatments and contraindications to chemoprophylaxis

Patient No.	Sex	Age	Previous failed treatment	Reason not to perform prophylactic therapy
1	M	37	Cyclosporine, methotrexate 15 mg/week	Hepatotoxicity was reported during treatment with methotrexate
2	M	77	Cyclosporine 3 mg/kg	Hypercholesterolemia
3	F	68		Increased liver enzymes due to treatment with carbamazepine (400 mg ×3/die)
4	M	73	Acitretin	Autoimmune hepatitis in treatment with azathioprine 100 mg ×2/die and prednisone 10 mg/die
5	M	53	Cyclosporine	Antiviral therapy with high level of liver enzymes for treatment of HCV infection
6	M	63	Methotrexate	Pulmonary fibrosis and hepatotoxicity, methotrexate related
7	F	50	Acitretin, methotrexate	Refused the prophylactic therapy
8	M	64	Cyclosporine, methotrexate	Methotrexate hepatotoxicity
9	M	38	Cyclosporine	Alcoholism
10	M	29	Cyclosporine, methotrexate	Refused the prophylactic therapy
11	M	73	Acitretin 25 mg and methotrexate	Elevation of liver enzymes due to the statin therapy
12	F	46	Cyclosporine	Poor tolerability to prophylactic therapy