Table 2.
The levels of different parameters in varying stages of CKD
| Stage 1,2 a | Stage 3 b | Stage 3 c | Stage 4,5 d | P value | Post hoc tests | |
|---|---|---|---|---|---|---|
| Plasma cf-mtDNA (GE/mL) | 523 ± 710 | 373 ± 360 | 420 ± 664 | 112 ± 134 | 0.209 | |
| Plasma cf-nDNA (GE/mL) | 1269 ± 1195 | 698 ± 527 | 439 ± 569 | 104 ± 70.01 | <0.001** | a > b,c,d |
| Urine cf-mtDNA (GE/mL) | 0.43 ± 0.69 | 0.98 ± 3.10 | 2.78 ± 10.12 | 6.49 ± 17.85 | 0.220 | |
| Urine cf-nDNA (GE/mL) | 2.83 ± 4.60 | 4.49 ± 12.09 | 15.39 ± 44.01 | 8.01 ± 12.08 | 0.351 | |
| Plasma NGAL (ng/mL) | 394 ± 175 | 489.6 ± 174.9 | 744.2 ± 272.1 | 1096 ± 488.7 | <0.001** | a,b,<c,d |
| MCN (per cell) | 90.7 ± 66.9 | 94.9 ± 77.01 | 92.9 ± 89.9 | 110.5 ± 112.7 | 0.901 | |
| Urine 8-OH dG/Cr | 3.73 ± 1.81 | 3.78 ± 2.93 | 4.15 ± 2.65 | 2.99 ± 1.53 | 0.416 |
P-value by One-Way ANOVA follow with Bonferroni multiple comparisons at type I error of 0.05 level
*P <0.05, **P <0.01
Post hoc a indicates group stage 1,2; b indicates group stage 3a; c indicates group stage 3b; d indicates group stage 4,5
MCN mitochondrial copy number, NGAL neutrophil gelatinase-associated lipocalin; 8-OH dG 8-hydroxy-2-deoxyguanosine, cf-mtDNA cell-free mitochondrial DNA, cf-nDNA cell-free nuclear DNA, GE/mL genome equivalents/mL