Table 3.
Favorable renal outcome (n = 53) |
Unfavorable renal outcome (n = 70) |
P value | |
---|---|---|---|
Plasma cf-mtDNA (GE/mL) | 441.1 ± 525.6 | 370.6 ± 641.9 | 0.538 |
Plasma cf-nDNA (GE/mL) | 760.9 ± 732.9 | 554.1 ± 850.9 | 0.184 |
Urine cf-mtDNA (GE/mL) | 0.489 ± 0.751 | 3.745 ± 12.197 | 0.027* |
Urine cf-nDNA (GE/mL) | 1.764 ± 2.388 | 15.119 ± 40.791 | 0.009* |
MCN (per cell) | 87.21 ± 69.40 | 101.55 ± 95.75 | 0.356 |
Urine 8-OH dG/Cr | 3.62 ± 2.44 | 4.03 ± 2.44 | 0.346 |
NGAL (ng/mL) | 585.24 ± 251.62 | 780.85 ± 391.39 | 0.032* |
*P < 0.05, Student’s test
MCN, mitochondrial copy number; NGAL, neutrophil gelatinase-associated lipocalin; 8-OH dG, 8-hydroxy-2-deoxyguanosine; cf-mtDNA, cell-free mitochondrial DNA; cf-nDNA, cell-free nuclear DNA; GE/mL, genome equivalents /mL
Favorable renal outcome indicated eGFR at 6 months minus baseline eGFR> = 0; unfavorable renal outcome indicated eGFR at 6 months minus baseline eGFR <0