Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 12;11(8):1464–1478. doi: 10.1080/19420862.2019.1660564

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

PMC Copyright notice

Figure 5. — PK profiles of engineered antibodies and heterodimeric IgGs in Sprague-Dawley rats. Blood concentrations over time are shown. Antibodies and heterodimers were administrated at 10 mg/kg in a single intravenous bolus injection. Data points represent the mean concentration ± SD. (a) PK profile comparison of engineered antibodies: trastuzumab dA (IgG dA) and trastuzumab dG (IgG dG) vs. trastuzumab analog (IgG1). (b) PK profile comparison of the different heterodimeric IgGs. The trastuzumab analog profile (IgG1) generated from the same in vivo experiments is shown, heterodimers as indicated. (A-) denotes a nonfunctional PA binding site. (G-) denotes a nonfunctional PG binding site. (*) denotes the presence of the L234A and L235A substitutions in both BEAT Fc chains (Eu numbering).