Table 3.
PK parameters of engineered antibodies following a single IV bolus injection in female Sprague-Dawley rats.
| PK parameter | IgG1 | IgG dG | IgG dA |
|---|---|---|---|
| Cmax (µg/ml) | 351 ± 8 | 281 ± 51 | 238 ± 21 |
| AUC0-inf (hr*µg/ml) | 45318 ± 4025 | 36176 ± 4022 | 23564 ± 1328 |
| CL (ml/day/kg) | 5.3 ± 0.4 | 7.2 ± 1.4 | 10.1 ± 0.6 |
| Vss (ml/kg) | 77 ± 7 | 83 ± 8 | 117 ± 4 |
| t1/2 (day) | 10.4 ± 2.4 | 9.5 ± 0.5 | 11.8 ± 0.6 |
(AUC0-inf) area under the serum concentration-time curve from time zero to infinity. (CL) clearance. (Cmax) maximum serum concentration. (t½) elimination half-life. (Vss) apparent volume of distribution at steady state. Standard deviation for each parameter is indicated.