Table 6. Significantly enriched KEGG pathway of hub genes.
| Pathway ID | Terms | Gene count | P-Value | Genes |
|---|---|---|---|---|
| hsa04668 | TNF signaling pathway | 4 | 5.54E−08 | CXCL1, CCL20, IL6, SELE. |
| hsa04066 | HIF-1 signaling pathway | 3 | 6.38E−06 | IL6, SERPINE1, TIMP1. |
| hsa04060 | Cytokine-cytokine receptor interaction | 3 | 9.63E−05 | CXCL1, CCL20, IL6. |
| hsa04621 | NOD-like receptor signaling pathway | 2 | 0.000199993 | CXCL1,IL6. |
| hsa04610 | Complement and coagulation cascades | 2 | 0.000364662 | SERPINE1,PLAUR. |
| hsa04620 | Toll-like receptor signaling pathway | 2 | 0.000671108 | IL6,TLR2. |
| hsa04062 | Chemokine signaling pathway | 2 | 0.00200085 | CXCL1,CCL20. |
| hsa04151 | PI3K-Akt signaling pathway | 2 | 0.006358451 | IL6,TLR2. |
| hsa04672 | Intestinal immune network for IgA production | 1 | 0.016724268 | IL6 |
| hsa04623 | Cytosolic DNA-sensing pathway | 1 | 0.022711959 | IL6 |
| hsa04115 | p53 signaling pathway | 1 | 0.02481751 | SERPINE1 |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 1 | 0.029714789 | IL6 |
| hsa04068 | FoxO signaling pathway | 1 | 0.047713858 | IL6 |
Notes.
- KEGG
- Kyoto Encyclopedia of Genes and Genomes