Table 1.

Product aggregation in scale-up and bench scale VI runs.

Scalea	Scale-up	Bench
Vessel	SUM-100	Glass Beaker
Maximum Volume	100 L	50 mL
PAE volume	66.5 L	25 mL
VIA pH	3.6	3.6
VIN pH	5.5	5.5
Mixing	Yes	Yes		Nob
VIA pool HMW	1.7%	1.3%	3.5%
VIN pool HMW	7.1%	2.4%	13.0%

^aStarting material was a PAE at a concentration of 28 g/L and HMW of 1.2%.

^bAcid titrant was added with no stir bar mixing, followed by a static hold of the VIA pool for 5 min.