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. 2019 Sep 17;11(8):1402–1414. doi: 10.1080/19420862.2019.1661736

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — Tetrameric scaffolds of DuoMabs are confirmed by class averages derived from micrographs recorded with negative stain transmission electron microscopy on antigen cMET binding DuoMabs (a, top row), as well as such binding antigen ErbB3 (a, bottom row). The Fc parts can be discriminated from Fabs because of their triangular shape and hole (yellow arrows in a). The Fabs are found in side as well as top views, with or without their central hole (white arrows in a). Scale bar represents 10 nm; all boxes are 31 by 31 nm. Small-angle X-ray scattering (SAXS) based on the ErbB3-specific DuoMab indicates that DuoMabs have a near-planar structure (b). Fit of calculated scattering profiles of different DuoMab models to the observed scattering profile of DuoMab: tetrahedral homology model (red, χ² = 4.8), planar homology model (green, χ² = 2.0), near-planar model obtained by a combination of rigid body and flexible modeling (blue, χ² = 1.5).