Table 2.
Odds ratio | 95% CI lower | 95% CI upper | P-value | |
---|---|---|---|---|
Aβ status ∼ SCD + covariates: AUC = 66.2 | ||||
SCD+ | 1.58 | 1.21 | 2.07 | 0.006 |
Female | 1.32 | 0.97 | 1.79 | 0.08 |
Age | 1.09 | 1.06 | 1.11 | <0.001 |
Aβ status ∼ APOE + covariates: AUC = 74.8 | ||||
APOEε4+ | 4.94 | 2.08 | 11.72 | <0.001 |
Female | 1.29 | 1.05 | 1.60 | 0.11 |
Age | 1.10 | 1.09 | 1.12 | <0.001 |
Aβ status ∼ SCD + APOE + covariates: AUC = 74.7 | ||||
SCD+ | 1.52 | 1.17 | 1.98 | 0.01 |
APOEε4+ | 4.87 | 3.47 | 6.89 | <0.001 |
Female | 1.24 | 0.90 | 1.72 | 0.20 |
Age | 1.11 | 1.08 | 1.14 | <0.001 |
Aβ status ∼ SCD*APOE + covariates: AUC = 74.8 | ||||
SCD+ | 1.56 | 1.05 | 2.34 | 0.03 |
APOEε4+ | 5.04 | 3.11 | 8.24 | <0.001 |
APOEε4+:SCD+ | 0.95 | 0.69 | 1.32 | 0.89 |
Aβ status ∼ SCD*APOE*Age + covariates: AUC = 74.8 | ||||
SCD+ | 1.66 | 1.08 | 2.58 | 0.02 |
APOEε4+ | 5.17 | 3.15 | 8.61 | <0.001 |
Age | 1.12 | 1.07 | 1.17 | <0.001 |
APOEε4+:Age:SCD+ | 1.06 | 1.00 | 1.13 | 0.25 |
Aβ status ∼ SCD*APOE*Sex + covariates: AUC = 75.7 | ||||
SCD+ | 1.51 | 0.83 | 2.75 | 0.18 |
APOEε4+ | 10.74 | 5.18 | 22.94 | <0.001 |
Female | 1.38 | 0.78 | 2.45 | 0.28 |
APOEε4+:Female:SCD+ | 6.60 | 1.63 | 25.32 | 0.007 |
Aβ status ∼ SCD + covariates in female APOEε4 carriers (n = 150) | ||||
SCD+ | 3.34 | 1.65 | 7.00 | 0.001 |
Age | 1.09 | 1.04 | 1.16 | 0.001 |
Aβ status ∼ SCD + covariates in male APOEε4 carriers (n = 97) | ||||
SCD+ | 0.37 | 0.13 | 1.00 | 0.05 |
Age | 1.21 | 1.12 | 1.34 | <0.001 |
Abbreviations: APOE, apolipoprotein E; AUC, area under the curve; SCD, subjective cognitive decline.