. Author manuscript; available in PMC: 2019 Oct 28.

Published in final edited form as: Mod Pathol. 2014 Sep 5;28(2):187–200. doi: 10.1038/modpathol.2014.109

TABLE 4:

Sensitivity and Specificities of Selected Stains and Combination of Stains

	Sensitivity %	Specificity %	Area under Curve*	Confidence Interval (95%)
S100 (−)	58	100	0.757	0.639-0.875
SOX10 (−)	75	100	0.878	0.790-0.967
Neurofibromin (−)	68	100	0.838	0.738-0.938
p16 (−)	73	100	0.919	0.846-0.992
EGFR (+)	69	100	0.878	0.790-0.967
p75NTR (+)	80	69	0.765	0.639-0.892
EGFR (+) or Neurofibromin (−)	84	100	0.919	0.846-0.992
EGFR (+) or p16 (−)	89	100	0.946	0.885-1.006
p16 (−) or Neurofibromin (−)	89	100	0.946	0.885-1.006
EGFR (+) or p16 (−) or Neurofibromin (−)	92	100	0.959	0.907-1.012
Ki67>20%	87	96	0.914^{^}	0.840-0.988

(−): Diffuse loss, expression in less than 5% of tumor cells; (+): positive, expression in 5% or more of the tumor cells;

^{^:}

Continues variables (percentage of positive cells) were used to create receiver operating characteristics curve and 20% was chosen as cut-off.