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(A) Each DNA molecule is tagged with a unique molecular barcode and patient barcode. DNA-seq libraries are prepared, captured for the regions of interest and sequenced. The UMIs are used for correction of errors introduced during PCR and sequencing. (B) UMI-based proofreading reduces error-associated noise. KRAS exons 2 and 3 are shown, highlighting reduction in background error rate in a representative sample.
